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It was the discovery of melatonin synthesis in endocrine body organs, particularly the pineal gland, neural structures, and immunocompetent cells such as T lymphocytes, NK cells, and mast cells that triggered the brand-new methods to the unifield signal guideline of homeostasis, which, at the turn of the 21st century, result in the production of a new important biomedical discipline - neuroimmunoendocrinology.
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